IsisPharma SG_B00CI2KP9O_US Serum Review
Our verdict
IsisPharma packs four active ingredients into a 30 ml exfoliating serum at $28.05, making it one of the more ingredient-dense options in this price range. The combination of ascorbic acid, glycolic acid, salicylic acid, and licorice targets the appearance of uneven pigment across all skin tones.
Check price on AmazonBest for
People dealing with the appearance of uneven skin tone or pigmentation who want a multi-acid approach with added vitamin C activity, across all skin types.
Skip if
Your skin is currently reactive, you are new to exfoliating acids, or you are pregnant (salicylic acid use during pregnancy warrants a doctor's guidance).
- Form Serum
- Skin type All
- Key ingredients Ascorbic Acid,Glycolic Acid,Licorice,Salicylic Acid
- Benefits Exfoliating
- Targets Uneven Pigment
- Size 30 Milliliters
- Priced 28% above the category median ($22.00 across 291 tracked models)
Our scorecard
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Owner rating4.5/5
4.5 average across 750 owner ratings
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Popularity3.2/5
750 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other anti-aging skincare: serums, night creams, facial peels, wrinkle patches and anti-aging devices we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
['IsisPharma brings a clinical, multi-ingredient philosophy to this serum. Ascorbic acid delivers vitamin C activity, glycolic acid provides alpha-hydroxy exfoliation, salicylic acid adds beta-hydroxy penetration, and licorice extract is often used for its potential role in supporting a more even-looking complexion.', 'At $28.05 for 30 ml, this sits at the accessible end of the clinical skincare market. The aloe scent keeps fragrance light, and the all-skin-tone designation means the brightening focus is designed to work broadly rather than for a narrow demographic.', 'With 750 ratings at 4.5 stars, the feedback base is solid enough to draw reliable conclusions. The exfoliating nature of the formula means some users with very sensitive skin may find the acid combination too active for daily use at first.']
Pros
- Four active ingredients at a $28.05 price point is strong value
- Targets the appearance of uneven pigment with both AHA and BHA acids
- Works across all skin tones
- Aloe-scented rather than heavily fragranced
- 4.5-star average across 750 reviews
Cons
- Multi-acid formulas can cause irritation, especially for sensitive or reactive skin
- 30 ml is a standard but not generous size for the price
- Not ideal for beginners unfamiliar with exfoliating acid serums
Specifications
- Form
- Serum
- Skin type
- All
- Key ingredients
- Ascorbic Acid,Glycolic Acid,Licorice,Salicylic Acid
- Benefits
- Exfoliating
- Targets
- Uneven Pigment
- Size
- 30 Milliliters
- Scent
- Aloe
- Skin tone
- All
Performance notes
Ascorbic acid is the active form of vitamin C, which may support the look of brighter, more even skin. Glycolic acid is an AHA that promotes surface exfoliation, potentially improving skin texture appearance over time. Salicylic acid, a BHA, penetrates into pores and may help with clarity. Licorice root extract contains glabridin, a compound often studied for its potential to support a more uniform skin tone appearance. Together these four create a formula with meaningful ingredient rationale.
What buyers say
A 4.5-star rating from 750 reviews suggests a reliably satisfied customer base. This review count is sufficient to see through outliers, and the score indicates most buyers find the product performs as expected. Results with brightening and exfoliating serums can take several weeks to become visible, which is worth keeping in mind when reading individual reviews.
Similar anti-aging skincare: serums, night creams, facial peels, wrinkle patches and anti-aging devices to consider
Frequently asked questions
Can this serum be used every day?
Formulas containing both AHA (glycolic acid) and BHA (salicylic acid) are often recommended for gradual introduction rather than immediate daily use. Starting two to three times per week and observing how your skin responds is a practical approach. Using SPF during the day is especially important when using exfoliating acids, as they can increase sun sensitivity.
What does this serum target?
The listed target is uneven pigment. The combination of ascorbic acid and licorice may support the appearance of a brighter, more even complexion over time, while the glycolic and salicylic acids work on surface texture and clarity. Results vary based on skin type and consistency of use.
Is IsisPharma a clinical or consumer brand?
IsisPharma is a dermocosmetic brand with roots in dermatology-focused formulation. It is generally found through pharmacies and skincare specialty retailers rather than mass-market channels. The clinical positioning is reflected in the multi-active formula design.